الفهرس | Only 14 pages are availabe for public view |
Abstract Fast dissolution of orally administered drug candidates is one of the most important factors for achieving the desired concentration at the absorption site. Rapidly dissolved drug molecules is capable of establishing high concentration gradient which is the driving force for gastrointestinal absorption of most drugs. The established concentration gradient can deliver the required drug concentration to systemic circulation to exert the pharmacological response. In recent years, combinatorial chemistry principles and extensive drug screening resulted in the development of enormous numbers of active pharmaceutical ingredients (APIs). Unfortunately, almost 35-40 %of developed APIs are unable to continue production cycle due to difficulty of fabrication into suitable dosage form. In most cases, this is due to limited aqueous solubility and erratic dissolution behavior of API. |