الفهرس 
Methods for Peptide Bond Formation
Characterization of Peptides Through Mass SpectrometryOnly 14 pages are availabe for public view
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Abstract
In recent years, the synthesis of pyrazolopyrimidine as well as peptide derivatives
become an area of interest of medicinal research.
Pyrazolopyrimidine are heterocyclic compounds that possess wide range of
biological activities such as anti-inflammatory, anti-tuberculosis, kinase inhibitor,
oxidase inhibitor, anti-cancer, anti-proliferative activity, anti-bacterial, analgesic,
anti-tumor and anti-diabetic activities, Thus in the present work, A series of
pyrazolo[3,4-d]pyrimidine derivatives were synthesized, regarding that the
introduction of a phenyl group provides compounds with increased lipophilicity
and activity when compared to their non-substituted analogues.
In addition to proceed coupling reaction of the Pyrazolopyrimidine acid hydrazide
derivatives with different amino acid esters; (Glycine, L-Alanine, L-Phenylalanine,
L-Valine, L-Leucine, L-Arginine)ethyl ester.HCl to obtain peptide derivatives
conjugated with a pyrazolo[3,4-d] pyrimidine residue.
The prepared compounds were tested for antitumor, antiviral, antimicrobial
activities which displaying different degrees of those activities.