الفهرس | Only 14 pages are availabe for public view |
Abstract In recent years, the synthesis of pyrazolopyrimidine as well as peptide derivatives become an area of interest of medicinal research. Pyrazolopyrimidine are heterocyclic compounds that possess wide range of biological activities such as anti-inflammatory, anti-tuberculosis, kinase inhibitor, oxidase inhibitor, anti-cancer, anti-proliferative activity, anti-bacterial, analgesic, anti-tumor and anti-diabetic activities, Thus in the present work, A series of pyrazolo[3,4-d]pyrimidine derivatives were synthesized, regarding that the introduction of a phenyl group provides compounds with increased lipophilicity and activity when compared to their non-substituted analogues. In addition to proceed coupling reaction of the Pyrazolopyrimidine acid hydrazide derivatives with different amino acid esters; (Glycine, L-Alanine, L-Phenylalanine, L-Valine, L-Leucine, L-Arginine)ethyl ester.HCl to obtain peptide derivatives conjugated with a pyrazolo[3,4-d] pyrimidine residue. The prepared compounds were tested for antitumor, antiviral, antimicrobial activities which displaying different degrees of those activities. |