الفهرس 
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Abstract
Duck enteritis virus (DEV) is one of the most duck disease threated duck industry especially Muscovy ducks flocks, Duck enteritis virus causing great economic losses due to high mortality rate , DROP in egg production and immunosuppressive effect that lead to secondary bacterial infection with E-coli and pasteurella anatipestifier and vaccination failure.
For studying the disease, samples from ducks suspected to be infected with Duck enteritis virus (DEV) of different breeds and ages were collected from 68 flocks from different six provinces in Egypt during period of 2016 to 2018.The clinical picture and post mortem lesions of DEV infection were observed among the examined flocks with mortality rate up to 75%.
The histopathological findings in field samples represented by presence of intranuclear inclusion bodies (IN\IB) in intestine and liver of infected birds. In addition to specific pathological lesions as multifocal necrosis with degenerative changes mainly fatty, hydropic and vacuolar changes in the liver, lymphocytes depletion of the white pulp of spleen, degenerative change in cardiomyocytes and interstitial edema in heart as well as severe necrotic enteritis in intestine.
The isolation of Duck Enteritis virus was carried out using 11-14 day old embryonated Muscovy duck eggs via Chorioallantoic membrane. Twenty nine samples out of 68 (42.6%) caused embryo mortalities within 4-10 days post inoculation, with the characteristic extensive haemorrhage on embryo, CAM was edematous, hemorrhagic with the presence of white round raised pock lesions. All allantoic fluids collected from first passage of inoculated eggs were negative to hemagglutination test.