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Abstract Sixty mature male albino rats Rattus norvegicus weighing (150-200gm) were obtained from the Laboratory Animal Housing Unit, Faculty of Veterinary Medicine, Zagazig Univeristy, Egypt. The animals were clinically healthy, kept under hygienic conditions in plastic cages with hard wood shaving as bedding. Animals were acclimatized to the laboratory conditions for 2 weeks before the experiment. They were maintained on basal ration and tap water ad-libtum and a photoperiod of 12/12 hrs light/dark cycle. The rats were divided into 6 groups as following: • 1st group: consists of 10 rats and kept as control. • 2nd group: consists of 10 rats, orally administered 1ml of aqueous extract of ginger for 90 days. • 3rd group: consists of 10 rats, orally administered 0.1 ml of Imidacloprid (1/100 LD50 =0.21 mg/kg b.w.) for 90 days. • 4th group: consists of 10 rats, orally administered 1ml of aqueous extract of ginger for 2 weeks followed by 0.1 ml of Imidacloprid for 90 days. • 5th group: consists of 10 rats, orally administered 0.1 ml of Imidacloprid for 90 days then 1ml of aqueous extract of ginger for 2 weeks. • 6th group: consists of 10 rats, orally administered 0.1 ml of Imidacloprid and 1ml of aqueous extract of ginger simultaneously for 90 days. |