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Abstract This study aimed to investigate the effect of lotus petals, seeds and their mixture as a powder on Initial weight, final weight, feed intake (FI), Feed Efficiency Ratio (FER), (BWG %) and relative organs weight of diabetic rats. The main target of the present investigation was to study the effect of serum glucose, lipid profile, liver function, kidney function and complete blood picture. Materials and methods: Lotus (Nelumbo nucifera) petals and seeds were obtained from herbalist in the month of January 2019 from Cairo, Egypt. Streptozotocin powder was obtained from El-Gomhoria Company, Cairo, Egypt. The experimental was done in the Faculty of Medicine Ain shams Research Institute. A total of 40 adult normal male albino rats Sprague Dawley strain weighing 140±10 g (about 6 weeks old) and fed for one week on basal diet prior to start feeding on experimental diet for acclimatization rats are divided into 2 Basic groups:. Thirty -five adult male albino rats, weighing 140± 10g were divided into six groups each with five rats. One of them was Negative Control Group, which fed on standard diet and tab water, injected by streptozotocin 40 mg/kg of rats body weight and used as a positive control group (fed on basal diet only). This group was further divided into the following subgroups: group 2: positive control group (untreated group). group 3: Treated with 2.5% lotus petals powder. group 4: Treated with 5% lotus petals powder. group 5: Treated with 2.5% lotus seeds powder. group 6: Treated with 5% lotus seeds powder. group 7: Treated with 2.5% mixture (1:1) of lotus (petals+ seeds) powder. |