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Abstract Polycystic ovary syndrome (PCOS) is responsible for more than 80% percent of anovulatory infertility and 4–6% of infertile women in general. PCOS patients in this study were diagnosed according to the following criteria: oligomenorrhea and/or amenorrhea; clinical and/or biochemical signs of hyperandrogenism; and transvaginal sonographic appearance of polycystic ovaries (20 follicles or more, 2–9 mm in their diameter or an ovarian volume ≥10 cm3). Lifestyle modifications and physical exercises are essential to lose weight in the obese PCOS patients. Clomiphene citrate is considered the first drug to be used for treatment PCOS patients while the second line includes gonadotropins or laparoscopic ovarian drilling (LOD) and the third is assisted reproductive techniques. The aim of this study is to compare between the effect of ovarian drilling using either fixed thermal dose or adjusted dose based on ovarian volume in case of PCOS resistant to Clomiphene citrate (CC) treatment in terms of menstrual regularity, serum Free testosterone level and pregnancy rate. This study found that regarding the resumption of menstrual regularity and achieving pregnancy after 6-month follow-up, LOD is effective without a statistically significant difference between fixed and adjusted |