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Abstract Unexplained infertility represents a significant clinical problem, the evaluation and management of which leave a lot to be desired. The lack of universally accepted diagnostic criteria makes it difficult to study this problem because of the heterogeneity in the samples selected for study. Agreement on the definitions is a first step in this process of creating homogeneous groups for study. The Practice Committee of the American Society for Reproductive Medicine (ASRM) has published guidelines for a standard infertility evaluation. It includes semen analysis, assessment of ovulation, hystero-salpingiogram, and/or laparoscopy, when the results of a standard infertility evaluation are normal, practitioners assign a diagnosis of unexplained infertility. Unexplained infertility account is approximately 15% to30%. H.pylori is a Gram-negative bacterium responsible for the large majority of chronic gastritis, peptic ulcers and mucosal-associated lymphoid tissue (MALT) lymphoma. The pathogenicity of H.pylori infection depend on the inflammatory response to chronic infection, including the strain-specific factors, the host’s immune response, and environmental factors. By the end of this study, data of 60 participants (30women in group 1 and 30 women in group 2) were statistical analyzed: The mean age of included women was 26.26 in cases group and 27.65 in control group. Regarding type of infertility in the study group 7 were complaining of secondary infertility (23.3%), and 23 women were complaining of primary infertility (76.7%).The mean of the duration of infertility in case group is 2.54. There was a significantly higher proportion of women with positive serum H.pylori antibodies among women with unexplained infertility 19 (63.3%), when compared to control women 10 (33.3%). There was a significantly higher proportion of women with positive cervical mucus H.pylori antibodies among women with unexplained infertility 16 (53.3%), when compared to control women 7 (23.3%). There was non significantly higher proportion of women with positive serum H.pylori antibodies among women with primary infertility 10 (43.5%), when compared to women with secondary infertility 4 (57.1%). There was non significantly higher proportion of women with positive cervical mucus H.pylori antibodies among women with primary infertility 5 (21.7%) when compared to women with secondary infertility 2 (28.6%). In Conclusion, in women with unexplained infertility, H.pylori IgG antibody in the serum and the cervical mucus was significantly prevalent compared with that in fertile women. |