الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
The aim of the study was to evaluate the serological rate of Helicobacter pylori (H. pylori) infection in HCV related liver cirrhotic patients ,determine its role in upper gastrointestinal bleeding whether variceal or not , and demonastrate its role in progression of liver disease.
The current study is a Prospective cross sectional study conducted on:-
group I: 100 patients of post hepatitis C liver cirrhosis presented with upper gastrointestinal bleeding. Age ranges between 40 to 83 years old; 56 male and 44 females, recruited from internal medicine department at Minia university hospital from march 2018 to december 2018.
group II: included 50 healthy subjects (28male and 22 females) as a control group matched for age and sex.
All patients will be subjected to following ;
1- Full history: age ,smoking status ,alcohol consumption , prescence of liver disease and its duration , prescence of chronic renal disease, history of current medication or previous medication for H.Pylori
2- Clinical examination:liver disease stigmata
3- Investigations
– Laboratory (CBC ,liverfunction ,renal function ,viral markers ,measure of H –Pylori specific Ig G)
- Radiology abdominal ultrasound
-Upper endoscopy : to detect source of upper GIT bleeding
Serum H.pylori IgG level was significantly higher in cases of liver cirrhosis with p- value of 0.001 when compared with control.
Serum H.pylori IgG level was significantly higher in cases with peptic ulcer with p- value of 0.033 when compared with both PHG and variceal bleeding in liver cirrhotic patients.
Serum H.pylori IgG level show significant difference among patients as regard severity (child classification) with p value of 0.001.
from our study we can concluded that:
1-The prevalence of H Pylori is higher in liver cirrhotic patients when compared with control
2-Helicobacter pylori has a role as risk factor for peptic ulcer in patients with liver cirrhosis.
3-H Pylori has a protective effect and not a promotive effect on variceal bleeding and PHG
4- There is significant statistical difference between group of cases as regard terms of child classification and h pylori IgG status which demonastrate role of HP in progression of liver disease.
5- H Pylori has a role as risk factor for thrombocytopenia and hepatic encephalopathy in liver cirrhotic patients.