الفهرس | Only 14 pages are availabe for public view |
Abstract SUMMARY he Global Initiative for chronic Obstructive Lung Disease (GOLD), a project initiated by the National Heart, Lung, and Blood Institute (NHLBI) and the World Health Organization (WHO), defines COPD as follows (GOLD, 2017): a common preventable and treatable disease, is characterized by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or gases. Exacerbations and comorbidities contribute to the overall severity in individual patients. Several studies have identified COPD as part of a systemic inflammatory syndrome and reported on the association of comorbidities like lung cancer, osteoporosis, progression of atherosclerosis, and CKD. One hundred and thirty subject were chosen from outpatient pulmonology clinic of Ain Shams University Hospitals and National Institute of Allergy and Chest Diseases, Ministry of Health at the period from October, 2017 till September, 2018 randomly and analysed. The age range from 40 to 60 years. The sex ratio 2:1 male to female. Twenty-one subjects were excluded according to exclusion criteria, 3 subjects died and 5 subjects lost during follow up. T Summary 98 The rest of subjects were 101 subjects, 80 subjects chosen randomly using randomization of SPSS version 21 and divided into four groups each group including 20 subjects Sixty patients were COPD pts. in contrast with Twenty normal controls. The participants (cases) were recognized by a full examination, history taking, measurement of pulmonary functions by spirometry, analysis of renal functions urea, creatinine and GFR. All patients and control persons were subjected to: A) History taking. B) Complete physical examination. c) Measurement of pulmonary functions by spirometry. d) Kidney function tests (Urea, Creatinine) e) Creatinine clearance by (Cockcroft-Gault Equation) Statistical Analysis was done using the Statistical Package for Social Science (IBM SPSS) version 23, showed that no statistically difference between the control and the study groups regarding the age, but statistically was highly significant difference between body weight and GFR in moderate group but, no significant difference in all patients group. Summary 99 Also, there was highly significant difference between severity of FEV1 and GFR in all patients group and severe group but, non-significant difference in mild and moderate groups. While, there was no significant difference between GFR and FEV1/FVC ratio in all patients group, there was highly significant difference between Creatinine value and GFR in all patients group and severe group but, no significant difference in mild and moderate groups. These study support the concept that chronic obstructive pulmonary disease (COPD) has an effect on Prevalence of chronic kidney disease |