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Abstract ICSI is now one of the most successful and viable techniques in assisted fertilization and revolutionized the treatment of male infertility. In those who have no identifiable or correctable cause, ICSI provides new hope for couple with male infertility.(Infertility is common and the global burden remains high over the years and it is used to overcome female or male fertility problems) (16). PPR has aroused interest as some authors have suggested decreased CPR with this phenomenon. The debate whether this subtle PPR negatively affects ICSI cycle outcome is still ongoing. The issue isn’t new but still unresolved, Schoolcraft et al, had 1st reported in 1991, that CPR is adversely affected by PPR.(92),4) In 1991, Schoolcraft et al & Silverberg et al. mentioned that a modest PPR was associated with lower PR and higher rate of AB in COS for ICSI, but the pathogenesis & effects remain controversial.(4, 6) Most studies used an absolute P-hCG as an indicator of PL, and the cut-off value differed (0.8 to 2 ng/mI). The threshold level for premature increase in serum P-hCG was arbitrarily defined within various studies.(166) The aim of study to study the P4-Hcg level effect on ICSI outcome including; the number of OR, oocyte quality, number & quality of ET and pregnancy outcome. |