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Abstract Nigella sativa (N. sativa) oil and its main constitute Thymoquinone (TQ) are both known for being effective on a broad spectrum of the biological pathways in living organisms. The present study aimed to investigate the effect of both N. sativa and TQ on the urothelial lesions induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in male Wistar rats. A six week old male Wistar rats were divided into four groups: The first group received no treatment as -ve control, the second group was treated with 0.05% BBN and 5% Sodium ascorbate as +ve control. The third group was treated the same as in the second group then was post treated with 200 mg/kg/b.wt. N. |