الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Liver is one of the most vital organs of vertebrates and some other animals. It is the body’s second large organ and is considered the biggest gland in the body
Liver HCV is distributed worldwide and one of these countries is Egypt mostly (genotype 4). Hepatitis C treatments today have been shown to be highly effective in curing the disease, with new generation drugs now able to treat even patients with cirrhosis who have failed previous therapies. The goal of hepatitis C treatment is to suppress the virus to the point where it becomes undetectable in blood tests and remains undetectable.
In this study Patients were divided in to 4 groups; Control group, Ribavirin plus sofosbuvir group, sofosbuvir plus simeprevir group and sofosbuvir plus simeprevir with ribavirin group.
Conclusions and recommendations
One oral dose of the triple therapy of sofosbuvir and simeprevir with ribavirin for 12 weeks seems to be the most effective combination treatment choices with the minimum adverse effects in chronic hepatitis C patients and high SVR rates almost 100%. While dual therapy of sofosbuvir and simeprevir appears to have the lowest rate of SVR.