الفهرس 
Introduction & Aim of the WorkOnly 14 pages are availabe for public view
 |  | from | 131 |  |  |
| | | from | 131 | | |
Abstract
Introduction: HCC is the most common primary liver cancer and its burden has been increasing in Egypt with a doubling in the incidence rate in the past 10 years. Up to 90% of HCC cases were attributed to HCV related cirrhosis. IL-18 is an inflammatory cytokines that participate in chronic hepatic inflammation leading to carcinogenesis. Methods: This study was conducted on 90 patients who were divided into three groups: group I (HCC group) included 33 patients with HCC on the background of liver cirrhosis due to chronic HCV. group II (cirrhotic liver group) included 37 patients with liver cirrhosis without any evidence of hepatic focal lesions. group III includes 20 healthy individuals. Results: This study revealed that the analysis of IL-18 single nucleotide gene polymorphism could be a valuable marker for prediction of progress towards cirrhosis in chronic HCV patients and also to subsequent development of HCC in HCV cirrhotic patients proved by the results of both GG genotype and its G allele in our studied patients without HCC. Conclusion: Our research showed that IL-18 single nucleotide gene polymorphism could be a valuable marker for prediction of progress towards cirrhosis in chronic HCV patients and also to subsequent development of HCC in HCV cirrhotic patients proved by the results of both GG genotype and its G allele in our studied patients without HCC.