الفهرس 
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Abstract
Background : Melatonin is a free radical scavenger and has antioxidant and anti-inflammatory properties It also has osteoinductive properties on bone. In periodontitis, osteocalcin has been suggested to be a marker of bone formation where bone resorption is greater than formation, and GCF osteocalcin levels are more revealing than serum or saliva levels regarding bone turnover in periodontium. Aim : The aim of this study is to investigate the efficiency of local Melatonin gel application as adjunct to scaling and root planning in the treatment of intrabony defects (IBDs) in chronic periodontitis patients and to assess the effect of melatonin gel on osteocalcin levels in the gingival crevicular fluid (GCF) in those patients. Patients and method : Split mouth design was utilized upon fifteen chronic periodontits patients. Clinical parameters (Gingival Index, Plaque Index, Clinical Attachment Level, probing Pocket Depth) were recorded at baseline and after twelve weeks of treatment. GCF samples were collected at baseline and twelve weeks after treatment to asses osteocalcin level. All patients received scaling and root planning once a week for one month, the test sites only were locally injected with Melatonin gel. Results : The clinical parameters (PI, GI, PD, CAL) showed much significant improvement in the study sites (SRP+Melatonin) than in control sites. Moreover the test sites showed statistically significant reduction in GCF OC than in control sites at p<0.001. Conclusion : The local application of melatonin gel offers a promising therapeutic approach in periodontal treatment as adjunct to SRP.