الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
One of the drug delivery system is the oral drug delivery which is the most desirable and preferred method of administering therapeutic agents for their systemic effects due to its ease of ingestion, pain avoidance, versatility, flexibility in dosage, strength, relatively stable, present lesser problem in formulation and packaging convenient to manufacturer, store and most importantly patient compliance. In addition, oral administration is generally considered as the first avenue investigated in the discovery and development of new drug entities and pharmaceutical formulations, mainly because of patient acceptance, convenience in administration and cost effective manufacturing process (Sing and Kim, 2007). However, there are many potential problems arise from multiple dose therapy such as the difficulty of achieving appropriate blood level within the therapeutic range at sufficiently early time points, the difficulty to maintain constant therapeutic levels of drugs with short half-lives, and patient noncompliance with the multiple-dose regimen (Ding et al., 2005). An appropriately designed sustained release (SR) drug delivery system can be a major advance toward solving these problems and overcoming some of the shortcomings of this route.