الفهرس 
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Abstract
Background and Aims: Monosodium glutamate (MSG) impairs the ovarian functions and induces oxidative stress. Kynurenic acid (KYNA) exerts its antioxidant effect by reducing reactive oxygen species (ROS) production in oocytes in a concentration-dependent manner and by its antiinflammatory effects. The present study intended to demonstrate the effects of MSG on ovarian tissue and to investigate protective effects of KYNA against MSG induced ovarian impairment. Methods: Thirty adult female albino rats were randomly divided into three equal groups: a) control group (received 0.5 ml distilled water by oral gavage for 14 consecutive days); b) MSG treated group (received 0.2 g/kg/day dissolved in 0.5 ml distilled water by oral gavage tube at 9 am daily for 14 days); c) MSG and KYNA treated group (received the same MSG doses of group II, together with KYNA solution in drinking water, at concentration of 25 mg/l for 14 days). Ovarian tissue was assessed in all groups histopathologically and biochemically; through determination of tissue malondialdehyde (MDA) and reduced glutathione (GSH). Serum FSH, LH and estradiol levels were also studied in all groups. Results: MSG treatment significantly increased the serum levels of FSH, LH and the ovarian levels of MDA. However, it significantly decreased the serum estradiol and the ovarian GSH levels when compared with control group. Treatment with KYNA showed a significant decrease in serum FSH, LH and ovarian MDA levels, together with a significant increase in the serum estradiol level and ovarian GSH level when compared with MSG treated group. Conclusion: We can conclude from these results that monosodium glutamate impairs the ovarian functions with a protective effect of kynurenic acid. Key words: MSG, ovarian functions, oxidative stress, KYNA, antioxidant, anti-inflammatory.