الفهرس 
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Abstract
Aptenia cordifolia belonging to family Aizoaeae as it a well-known groundcover, the species name cordifolia is derived from the Latin words, cordi, meaning heart, and folium, meaning leaf, is an evergreen and fast-growing succulent, often a short-lived perennial and 250 mm high. The roots are fleshy and thick; the succulent stems are four-angled or rounded and grow flat on the ground. Bladder or water cells are closely arranged on the surfaces of the stems and shine in the sunlight. Besides its popularity as ornamental plant with beautiful and elegant flower, A. cordifolia was traditionally used as anti-inflammatory and as addressing in South Africa. Phytochemical analysis has recently yielded a number of important phytocompounds, particularly alkaloids, with significant biological properties. The current study of A. cordifolia roots included:
Part I:
Metabolomics analysis.
Part II:
Phytochemical study of A.cordifolia including:
Phytochemical screening of A. cordifolia roots, Extraction, fractionation, isolation, and identification of different constituents from the roots of A. cordifolia.
Part III:
Biological study of A. cordifolia including:
Evaluation of the anticancer activities of different fractions of A. cordifolia roots in three cell lines, Screening of the antidepressant activity of the basic ethyl acetate fraction and docking of identified alkaloids from metabolomics, Evaluation of anti- HCV activity of different fractions of A. cordifolia roots.
As an untapped source of potentially important bioactive principles, A. cordifolia has attracted considerable phytochemical and biological attention due to its richness in several phytoconstituents. The present study of A. cordifolia has revealed the presence of varied principles, mainly alkaloids, amides, fatty acid, fatty alcohol, and sterols. Additionally, biological investigation of different extracts of A. cordifolia roots revealed noteworthy anti-depressant and ant-hepatitis c activities. On account of the obtained findings of the current work, the following points could be recommended:
1- Further phytochemical analysis of A. cordifolia is strongly recommended. Isolation of additional compounds along with further testing may well produce fertile fields for pharmacological research.
2- Further investigation in alkaloidal fraction to actually determine the compounds responsible for the anti-depressant and ant-hepatitis c activities.
3- The anti-depressant alkaloidal fraction can be hopefully considered in future studies for development of alternative anti-depressant medication
4- Evaluation of the safety, toxicity, and herb-drug interactions of this plant species as an important issue towards broadening of its use in future phytotherapy.