الفهرس 
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Abstract
A total of eighty adult male Sprague-Dawley rats, with average weight of about 200-250 g were obtained from the Animal Research Unit, Faculty of Veterinary Medicine, Zagazig University, Egypt. The animals were clinically healthy, kept under hygienic condition, housed in a metal cages with hard wood shavings as bedding, well ventilated, fresh drinking water ad libitum, with 12 hours light/dark cycle, at appropriate humidity (50-60%) and temperature (21-24 °C) and all animals were kept under similar environmental and nutritional conditions throughout the period of experiment. All experiments were approved by the institutional Animal Care and Use Committee of the Faculty of Veterinary Medicine, Zagazig University under approval number (ZU-IACUC/2/F/119/2019).
After the period of acclimatization and training on treadmill, eighty adult male rats were divided randomly into eight treatments (groups), each group contain 10 rats as the following; sedentary, sedentary and triton, sedentary and doping, sedentary and triton and doping, moderate exercise, moderate exercise and triton, moderate exercise and doping & moderate exercise and triton and doping groups of male rats.
The objective of the present investigation was to study the molecular mechanisms regarding the effect of doping with anabolic steroids such as high dose of testosterone as well as the extent of ameliorative action of physical activity (exercise) on reproductive performance in hyperlipidaemia male rat model through measurements of semen pictures and morphology including live dead ratio, sperm concentration, abnormalities and motility, biochemical analysis of serum including corticosterone hormone level and free testosterone, the activity of lipid peroxidation markers in testes including antioxidant (Catalase (CAT), Glutathione peroxidase (GPx) activity and Super oxide dismutase (SOD) activity) and lipid peroxidation (Malondialdehyde level (MDA). Moreover, gene expression of steroidogenesis pathways in testicular tissue will also carried out gene including StAR enzyme, CYP11A1, CYP17A1, HSD17B3, CYP19A1 (Aromatase), BAX, Bcl2, Casp 3, Fas and FasL genes.