الفهرس 
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Abstract
Obesity is considered one of the greatest public health problems of our time. It is associated with multiple metabolic comorbidities, including type 2 diabetes, hypertension and osteoarthritis.
The treatment of obesity with conservative measures (lifestyle modification strategies) or pharmacotherapy often fails to produce a permanent reduction in body weight. As a consequence, bariatric surgery is very effective approach in reducing body weight.
There are two ways in which bariatric surgery promotes long-term weight loss either by reducing stomach size, bypassing a portion of the intestine or a mixture of these two approaches. The mechanisms which underlie these consequences of bariatric surgery remain unclear, but they are likely to include effects upon peptide hormones.
In the current study, we aimed to assess the effects of bariatric procedures (sleeve gastrectomy, minigastric bypass and sleeve gastrectomy with loop bipartition) on GIT hormones (Ghrelin, secretin, PYY, GLP-1) and to compare the endocrinal effects of the three procedures.
Our study was a prospective one, conducted on 56 patients admitted to the bariatric unit in Minia University Hospital in the period from February 2018 to February 2019, 40 cases underwent sleeve gastrectomy, ten cases underwent minigastric bypass and six cases underwent sleeve gastrectomy with loop bipartition.The body mass index for all patients ranged from 38 -73 kg/m2.
As regard changes in GIT hormones, PYY and GLP-1 hormone levels increased in the three operations two-weeks and two-months postoperatively. PYY increased in sleeve gastrectomy with loop bipartition more than minigastric bypass and sleeve gastrectomy.
GLP-1 increased in minigastric bypass more than sleeve gastrectomy with loop bipartition and sleeve gastrectomy. Ghrelin hormone level decreased in sleeve gastrectomy with loop bipartition more than minigastric bypass and sleeve gastrectomy. Secretin hormone level decreased in sleeve gastrectomy and sleeve gastrectomy with loop bipartition and increased in minigastric bypass.
As regard changes in weight and BMI, sleeve gastrectomy with loop bipartition and minigastric approximately achieved the same weight loss two-weeks and two-months postoperatively more than sleeve gastrectomy.
In correlation between weight loss and levels of GIT hormones, it was proven to be a strong relation between both factors.
As regard comorbidities including in the current study, we have six diabetic patients underwent bariatric surgery, four cases underwent minigastric bypass and two cases underwent sleeve gastrectomy with loop bipartition. Sleeve gastrectomy with loop bipartition have better diabetic control than minigastric bypass and sleeve gastrectomy.