الفهرس 
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Abstract
Background: Vitiligo is acquired depigmentary disorder characterized by destruction of the epidermal melanocytes leading to the loss of the skin color. Oxidative stress has a major role in the aetiopathogenesis and in melanocytic destruction due to its accumulation in the melanocytes and the hazardous effects to all compartments of the cell. Even in long-lasting disease melanocytes are still present but these cells have lost their integrity and functionality.
Objective: The primary aim of the work was to evaluate the level of tissue E-cadherin in skin samples of active vitiligo patients in different anatomical areas and compare them with normal controls. The secondary aim was to evaluate tissue hydrogen peroxide levels in the same anatomical areas in an attempt to find a possible causal relationship between both in the pathogenesis of vitiligo.
Subjects: This is a case control study which was carried out at Department of Dermatology, Venereology and Andrology, Ain Shams university hospitals and New Cairo Police Academy Hospital from March 2018 till March 2019 on 20 Subjects were divided into two groups, group I included 10 patients having active vitiligo were recruited from the Dermatology outpatient clinic, Ain Shams university hospitals. group II included 10 non vitilignous controls (attended the dermatology or plastic surgery clinics for cosmetic problems) were included in the study.
Results: We found that H2O2 level is increased in NSV patients when compared with healthy individuals. While Ecadherin level is significantly decreased in nonlesional and perilesional skin compared to normal skin. These finding are enhancing the role of oxidative stress and defective cell adhesion in pathogenesis of NSV propose that increased oxidative stress indicated by elevated H2O2 might play a role in decreased cell adhesion that is manifested E-Cadherin.
Conclusion: As compared to controls, increased H2O2 levels were suggestive of oxidative stress in patients of vitiligo in our study. from our results we can conclude that vitiligo is not a disease confined to melanocytes only, keratinocytes also showed certain pathological changes in vitiliginous lesions. As functional and structural units with melanocytes, keratinocytes in depigmented epidermis may constitute a different microenvironment compared to those in normally pigmented epidermis. These differences include obvious loss of cell to cell adhesion between keratinocytes and melanocytes and between keratinocytes and each other, which in turn may affect the pigmentary system of the skin.