الفهرس 
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Abstract
Platelet-rich plasma (PRP) consists of autologous platelets
created by centrifugation. The platelet concentration is 4–7 times the
normal plasma concentration. Platelets secrete at least seven essential
protein growth factors involved in initiating wound healing. Recently,
PRP has attracted attention in the field of dermatology, specifically in
the aesthetic field for skin rejuvenation.
Loss of elasticity is one of the primary signs of skin aging,
followed by the appearance of visible wrinkles. Hyaluronic acid is
involved in maintaining skin hydration, The HA concentration in the
skin is determined by the complex balance between the skin’s
synthesis, deposition, and degradation.
Recent basic research supports the idea that HA and PRP
treatments can be advantageously associated without altering the
original relevant characteristics of both products. When both products
are injected, their effects might be additive to enhance the anabolic
function of dermal fibroblasts.
Microneedling also called ”percutaneous collagen production”
is a form of using instruments which contain rows of thin needles.
When these instruments are rolled over the surface of the skin, they
induce rapidly-healing micropunctures. So, collagen and elastin fiber
production is stimulated resulting in skin remodeling.
Microneedling acts also by creating transient aqueous transport
microchannels through the stratum corneum, thus increasing the
transcutaneous permeability. This procedure is called transdermal
drug delivery.
Summary
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Our study included thirty subjects who received facial
treatments with PRP and HA through microneedling every two weeks
and the results were evaluated through our assumed visual assessment
scale.
The results yielded statistically significant improvement
concerning skin texture, glow, acne, acne scars, wrinkles, wide pores,
pallor and firmness compared to baseline.
Moreover, patients showed marked satisfaction with the results
with minimal side effects including erythema and burning or itching
sensation that lasted only few hours. No persistent side effects were
observed and no patients were found to have any evidence of
inflammation or allergic reaction.
In conclusion, PRP plus HA derived through microneedling
represent a potentially effective and safe materials for skin
rejuvenation. They could be recommended for keeping the youthful
appearance of the skin without cosmetics. Also, microneedling is a
safe simple tool to deliver substances through skin with minimal pain
in hand with collagen synthesis induction.