الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Hepatocellular carcinoma (HCC) is one of the most prevalent cancers representing the sixth most common cancer worldwide. It is an international public health problem. It has been suggested that by 2030, this number will increase by 53% or up to over 1.2 million cases.
Multiple etiological factors including viral and environmental influences lead to liver cirrhosis, which is the main risk factor for HCC. The common causes of liver cirrhosis are chronic hepatitis B virus (HBV) infection or chronic hepatitis C virus (HCV) infection, alcohol, aflatoxin exposure and obesity. In Egypt, there is a high incidence of the disease as a result of a high level of viral exposure. It estimated to account for 40-50% of cases.
Multiple choices for the treatment of HCC consist of surgical resection, liver transplantation, trans-arterial chemoembolization and percutaneous local ablation. MWA is a strikingly promising modality for treatment of hepatic malignancies. The major obstacle in HCC treatment, despite the good control of treated lesions, is the intrahepatic recurrence. Therefore, it is crucial to find novel methods for early prediction of HCC recurrence.
The European Expert Panel recently recommended incorporating a biomarker-based predictive model in HCC management. The French Study group for Liver Transplantation reported a new predictive model for detection of HCC recurrence; the AFP score, based on tumor stage and AFP values and was delineated it to be superior to the Milan criteria in predicting recurrence and selection of HCC candidates.
The replication of chromosomal DNA is completed during mitosis, which is accurately regulated by a series of serine/threonine kinases (Mitotic kinases), among which Aurora kinases. Which are important for accurate genomic stability. Loss of this genomic stability due to deregulation of Aurora kinases is considered to be one of the driving forces to hepatocarcinogenesis.
The aim of this work is to study the predictive value of Aurora B kinase and Alpha fetoprotein score for the recurrence of hepatocellular carcinoma after local microwave ablation.