الفهرس 
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Abstract
Background : chronic periodontitis (CP) is an infectious disease resulting in inflammation within the supporting structures of teeth, loss of attachment and bone resorption. Bacterial pathogen from subgingival dental plaque which is the main etiologic factor in periodontitis, stimulate host cell to release proinflammatory cytokines. These cytokines recruit PMNs to the site of infection to kill microorganisms either by i.e oxidative or nonoxidative mechanisms. The majority of host tissue damage occurred during periodontitis results from an excessive or prolonged release of neutrophil enzymes and reactive oxygen species (ROS), rather than from the pathogenic bacterial products themselves. Carotenoids are powerful antioxidant agents which are important in the maintenance of overall health of an individual. Among the carotenoids, lycopene is the most potent antioxidant. Lycopene is a free radical scavenger and a broad-spectrum antioxidant. As 8-isoprostane is a highly sensitive marker for oxidative stress. So the aim of this study was to evaluate the effect of using lycopene gel in comparison to chlorhexidine gel as adjunctive aid to scaling and root planing (SRP) in the treatment of chronic periodontitis (CP) and evaluate the effect of these different treatment modalities on the GCF level of 8-isoprostane. Subjects and method: Forty chronic periodontits patients were involved in this study. Clinical parameters (Gingival Index, Plaque Index, Clinical Attachment Loss, and Probing Pocket Depth) were recorded at baseline and six weeks after treatment. Gingival crevicular fluid samples were collected at baseline and six weeks after treatment for the assessment of 8-isoprostane level. All patients received scaling and root planing. Results : at baseline, there was no significant difference regarding clinical parameters (gingival index, plaque index, clinical attachment loss, probing pocket depth). Regarding GCF 8-isoprostane level at baseline, a statistically significant difference was only found between group 4 and all studied periodontitis groups. However after treatment, the GCF 8-isoprostane level was found to be decreased in all periodontitis groups (1, 2 and 3). The highest mean value of GCF level of 8-isoprostane was for group 2 followed by group 3 then group 1 and the least value was noticed in healthy group. Comparing the post treatment value level of GCF 8-isoprostane between all periodontitis groups with the healthy group (group 4), significant difference was found between group 4 and either group 2 or group 3, and nonsignificant difference was found between group 4 and group 1. Conclusion: Locally application of lycopene as adjunctive therapy to scaling and root planning could be an effective treatment of chronic periodontitis.