الفهرس 
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Abstract
Lichen planus is a relatively common, chronic mucocutaneous disease of unknown etiology. Classic cutaneous lesions are characterized by purple, polygonal, pruritic papules also, it can affect mucous membranes most commonly oral mucosa that may appear as lacy white patches or sores that can be painful.
The exact pathogenesis of the disease remains unclear. Lichen planus is considered to be an immune- mediated reaction involving activated T lymphocytes, particularly CD8+ T cells, against basal keratinocytes. Activated T-cells release cytokines that play an important role in the exacerbation of LPSquamous cell carcinoma antigens I and II (SCCAI and II, SERPIN B3 and B4), members of the ovalbumin serpin (ov-serpin) / clade B serpin family, were originally discovered as tumor-specific antigens and are used as tumor markers for various kinds of squamous cell carcinomas .They are involved in the pathogenesis of several inflammatory diseases: asthma, psoriasis and AD. Serum SCCA production from human keratinocytes in vitro. Accordingly, the SSCCA level does not result specifically from the IL-17-mediated inflammation but also from T-helper type2 (Th2) inflammation.
The aim of this study was to evaluate the serum levels of SCCA II in patients with oral and cutaneous LP and compare it to its level in control group.
The current study included 80 patients with LP (40 patients with cutaneous LP and 40 patients with OLP). In addition to 20 apparently healthy individuals of matched age and sex as a control group. The patients were subjected to full history taking, clinical examination and laboratory investigations including serum levels of SCCAII using ELISA technique.
The results of this study were summarized as the following
Serum levels of SCCAII were significantly higher in patients with LP compared to healthy control subjects.
Serum levels of SCCAII were significantly higher in patients with OLP compared to patients with cutaneous LP.
Serum levels of SCCAII were significantly higher in patients with actinic type of cutaneous LP compared to both hypertrophic type and classic type and there was no significant difference between hypertrophic type and classic type.
Serum levels of SCCAII were significantly higher in patients with ulcerative type of OLP compared to both reticular type and others. There was no significant difference between reticular type and others.
Serum levels of SCCAII were significantly higher in patients with ulcerative type of OLP compared to actinic type of cutaneous LP.
Serum levels of SCCAII were significantly higher in patients of OLP with positive HCV Ab compared to those with negative HCV Ab.
There were statistical significant positive correlation between SSCCAII and both duration and course of LP.
There were no statistically significant correlation between serum levels of SCCAII and both patients’ age and sex.