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Abstract This study was designed to investigate the effect of Moringa oleifera and Sweet basil as a natural feed additives on chicken production performance, complete blood pictures, immune response and antioxidant parameters in normal and experimentally infected chickens with E.coli. A total of 120 unsexed one- day- old, broiler chickens (Cobb) were randomly assigned to 6 treatment groups each of 20 as follows: G1 as the control;G2 received 5% Moringa oleifera supplement; G3 received 0.5% Sweet basil;G4 infected by E.coli only; G5 infected and treated by 5% Moringa oleifera and G6 infected and treated by 0.5% Sweet basil. Our work revealed growth promoter effect by increase body weight in the group fed 0.5 % Sweet basil and non-significant increase in body weight in the group fed 5 % Moringa oleifera at the end of experiment. Clinicopathological investigation showed non- significant change in RBCs, PCV and Hb in Moringa oleifera and Sweet basil treated groups. There was normocytic normochromic anemia and a significant increase in TLC and lymphocyte in infected non treated group. Also, treated groups and infected treated groups showed a significant increase in TLC and lymphocyte, but less than the infected group. ALT and AST showed a significant increase in infected group, while infected treated groups showed a significant decrease as compared with the infected group. Serum total protein and albumin showed a significant decrease with a significant increase in globulin in infected group. While infected treated groups showed a significant increase in total protein and albumin as compared with the infected group. Serum glucose and cholesterol showed a significant decrease in infected group. While infected treated groups showed a significant increase in glucose and cholesterol as compared with the infected group. Uric acid and creatinine concentrations showed a significant increase in infected group. While infected treated groups showed a significant decrease in uric acid and creatinine as compared with the infected group. Immunological investigation revealed a significant increase in IgM, IgG and IL6 in infected group. While infected treated groups showed a significant decrease in IgM, IgG and IL6 as compared with the infected group. Regarding antioxidant parameters, the serum MDA level was significantly increased while the serum SOD and GSH levels were significantly decreased in infected group. While infected treated groups showed a significant decrease in MDA with a significant increase in SOD and GSH levels as compared with the infected group. While the supplemented groups by Moringa and Sweet basil were improved the general health of chickens. |