الفهرس 
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Abstract
Preeclampsia (PE) is an obstetric complication affecting about 6–8% of pregnant women worldwide. Preeclampsia onset may be early in the 20 th gestational week and continue for 6 weeks postpartum. Preeclampsia is diagnosed by hypertension with arterial blood pressure ≥140/90 mmHg, proteinuria more than or equal 0.3 g/d, edema and any symptoms or signs of end organ dysfunction. Preeclampsia has increased incidence of morbidity and mortality (1). The pathogenesis of PE is unknown. During the first trimester, the abnormal placental invasion and the release of placenta-derived adverse factors is considered to be the main cause of the severe injury to the maternal endothelial tissue and systemic inflammatory response including several organs and systems in late pregnancy (2). Reliable prediction of PE plays a very important role in early intervention and prevention, this is because there is no effective treatment of preeclampsia rather than termination of pregnancy (3). Preeclampsia is divided into two degrees, mild PE (m PE) and severe PE (s PE), and there are different treatments and clinical outcomes for each one (4). The balance between coagulation and anticoagulation is important for the utero-placental circulation and organ perfusion in pregnant females. A proper rise in coagulative function is vital for healthy pregnant to decrease postpartum hemorrhage and any other complications (5).In women with PE, the coagulation-fibrinolytic system is one of the most seriously affected systems by maternal inflammatory reactions and immune dysfunction (6). When this balance is upset in women with PE, the blood stream of the placenta and many organs is blocked by microthrombosis (7).The super-hypercoagulable state of women with PE may also lead to systematic disorders of metabolism as well as multiple organ dysfunction and may even threaten maternal and fetal lives. So, coagulative and fibrinolytic status is a good predictor for the onset and clinical degree of PE (6)