الفهرس 
Introduction and Aim of the workOnly 14 pages are availabe for public view
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Abstract
Many search for new anticancer compounds still continued to avoid the harmful effects. Of chemicals and radiations on the host.propolis is a honey bee product with a complicated chemical compound due to its elevated content of polyphenolic component such as flavonoids, terpenoids, tannins. In the present study, the major objective was to improve propolis bioavailability using a nanosuspension formulation. The cytotoxic effect of propolis nanosuspension (pro-ns) on the ehrlich ascites carcinoma (eac) in female swiss albino mice was investigated in comparison to the free propolis. Materials and methods a propolis-loaded nanosuspension was formulated by applying solvent-antisolvent nano-precipitation technique. The prepared pro-ns wascharacterized for average particle size, polydispersity index (pdi) and zeta potential. Also, the morphology of the nanosuspension particles was investigated using scanning electron microscopy (sem). Moreover, pro-ns cytotoxicity was tested using eac bearing mice. The an-ticancer activity of pro-ns was assessed by studying tumor volume, life span, viable and non-viable cell count, antioxidant, biochemical estimations and proliferation of eac cells. Results the results revealed that propolis nano-particles were relatively spherical in shape with rough surface. The tumor bearing mice treated with pro-ns showed increased life span and inhibited tumor growth and the proliferation of eac cells in comparison to the free propolis (p < 0.01). Moreover, pro-ns ameliorated the increase in serum as-partate transaminase (ast) and alanine transaminase (alt) activities, igm and the level of creatinine and urea after implantation of eac cells. In addition, pro-ns improved the sod activity and glutathione content of liver and eac cells. Furthermore, pro-ns inhibited the formation of lipid peroxidation products (mda) and total igg in eac tumor bearing mice.