الفهرس | Only 14 pages are availabe for public view |
Abstract Liver diseases are among the most serious aliment. They may be classified as acute or chronic hepatitis (Inflammatory Liver Diseases), hepatitis (Non- Inflammatory Diseases) and cirrhosis (degenerative disorder resulting in fibrosis of the liver) . Carbon tetrachloride (CCl4) has been widely used in animal models to investigate chemical toxin-induced liver damage.The most remarkable pathological characteristics of CCl4 inducedCirrhosis are fatty liver, cirrhosis and necrosis . Phototherapy is the treatment and prevention of diseases using plants or plants part, such as leaves, flowers, roots, fruits, seeds, and rhizomes. Preparation made from them called medicinal plants, or herbs. Many plants were suggested to ameliorate or care the liver diseases, among them were the chia. Medicinal plants have very important place as they not only maintain the health and vitality of human beings and animals, but also cure several disease, including liver disorders without causing any toxicity . The present study investigated the effects of chia seeds on CCl4 induced Cirrhosis in rats . Thirty male albino rats were divided into (5) groups )6) rats in each group. Two groups were controls, one fed on basal diet only as a negative control and the other one fed on basal diet after injection with CCl4 as a positive control. The other groups were injected by CCl4 then received basal diet containing chia seeds at the levels of 2.5, 5 and 10 % . Liver damage was assessed by estimation of serm concentration of enzymes activities of aspartate amino transferase (AST), alanine amino transferase (ALT), lipid fraction (total cholesterol and triglyceride), cholesterol fraction (HDL-c, LDL-c, VLDL-c), Uric acid, Urea nitrogen and glucose. Results showed an improvement in case of tested seeds at the level of 5% followed by the level of 10% for the above parameters. So, this study concluded that CCl4 induced liver damage in rats can be ameliorated by administration of 5% chia seeds. |