الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Monosodium glutamate (MSG) is the sodium salt of glutamic acid and it is a non- essential amino acids which is widely used as flavor enhancer so increases the sapidity of food and enhances the flavor of foods. So, it is used in in home as well as in restaurant cooking and it is a popular component of Asian diets. MSG causes overfeeding leading to obesity. However, MSG causes disturbances in many tissues as central endocrine axis, excitotoxic damage and pancreatic cells damage, endocrine disorders, retinal degeneration, addiction, epilepsy, brain trauma, neuropathic pain, anxiety, depression, parkinson’s disease, stroke, Alzheimer’s disease and headaches. It also changes blood testosterone and estradiol levels and causes male infertility. Moreover, MSG causes oxidative stress resulted from reactive oxygen species (ROS) which attack polyunsaturated fatty acids and protein of membrane leading to cellular injuries. This takes place in all organs including the liver, where the metabolism of most foreign compounds occurs. On the other hand, several beneficial therapeutic effects of graviola (G) have been experimentally documented which include improvement in liver function and hematological parameters. Therefore, this study was designed to investigate the possible protective effects of GE (200 mg/kg bw) on the liver toxicity and complete blood count disturbance induced by MSG at a dose level of (100 mg/kg bw) for four weeks. The present experiment was carried out on 30 male Wistar albino rats weighing 100±10 gm. Conclusion: 1-The results of the present study illustrated that the extract of graviola (GE) exerted protective effects against the hepatic and hematological parameters disorders induced by the food additive MSG.2- The protective impact of GE might be attributed to phytochemical components of GE as acetogenin, antioxidants, phenolic compounds and other phytochemical activities reduced oxidative stress and improved the antioxidant status as well as inflammatory and apoptotic markers. This led to improvement in the various investigated parameters and was more pronounced in the group treated by GE before MSG.