الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
SUMMARY
A number of substituted dihydropyrimidine and thiazole based pyrimidine nucleus
and their sugar derivatives were synthesized.
Compound 1 was reacted with urea,thiourea and/or semicarbazide,thiosemicarbazide
to give the substituted tetra hydro pyrimidine derivatives 2a,b and 3a,b respectively.
H3C
O
O
Cl
NH
HN
Cl
X
O
H3C
2a; X=O
2b; X=S
H2N
X
NH2
KOH/ EtOH
1
2a,b
Summary
b
Reaction of 1 with diethylamine in ethanol produced 2.1.2 3-(4-Chlorophenyl)-3-
(diethylamino)-1-(p-tolyl) prop-2-en-1-one (4)
Reaction of 1 with Carbon disulfide in alcoholic sodium hydroxide afforded the
(4-(4-Chlorophenyl)-2-thioxo-1,3-oxathiolan-5-yl)(p-tolyl)methanone (5)
Aminothioxopyrimidine 3b reacted with the monosaccharides; D-glucose or Dgalactose
as six carbon sugars and D-xylose as five carbon sugars, in ethanol and
few drops of glacial acetic acid, compounds 6-8, respectively have been afforded
which have been shown to incorporate sugar moieties in the cyclic form.
Summary
c
The acetylated derivatives 9-11 were produced by acetylation of compounds 6-8
with acetic anhydride in dry pyridine.
Compound 2b was reacted with formaldhyde in the presence of pipridine to give
the corresponding Mannich base derivatives.
Summary
d
The ester 13 was produced by the reaction of 2b with ethyl chloroacetate, in the
presence of anhydrous potassium carbonate.
NH
HN
Cl
O
S
H C
2b
N
N
Cl
O
S
OCH CH
O
H C
13
ClCH COOEt
The thiazolo[3,2-a]pyrimidine-3,6(2H,7H)-dione 14 was prepared from compound
2b in one step by heating with chloroacetic acid and chlorobenzaldhyde in acetic
acid/acetic anhydride mixture in the presence of sodium acetate.