الفهرس 
Anatomy of ColorectumOnly 14 pages are availabe for public view
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Abstract
Colorectal cancer (CRC) is one of the leading causes of cancer mortality worldwide. Early detection and intervention in CRC patients and adenoma patients with a high risk of malignant transformation are effective in reducing cancer-associated mortality.Colonoscopy is considered as the routine tools for colorectal polyps screening, together with polyps removal and histopathology examination as the secondary prevention routine test of CRC, but it is difficult to differentiate between high grade dysplastic adenomatous lesions & early invasive carcinoma histopathologically. Biomarkers provide opportunities to understand cancer development and also to evaluate the efficacy of intervention.The aim of our work was to study the expression of FAP and PCNA in neoplastic colonic epithelial lesion and also correlation of their roles in adenoma carcinoma sequence as FAP is a stromal marker expressed in CAFs for detection and evaluation of early invasiveness of tumor and PCNA is a proliferating marker expressed in nuclei of proliferating cells.The present work included two groups; benign colorectal epithelial tumors compromising 25 cases and malignant colorectal epithelial tumors compromising 55 cases. Both groups showed male predominance and majority were of left sided colonic location.In included benign colorectal epithelial tumors patients age ranged from 43 to 71 years with mean value 57.2±6.79 and those cases had male predominance representing 60%. Majority of cases were of tubulovillous type representing 56%, then villous type representing 16% followed by tubular type representing 12 % and according to the degree of dysplasia majority of cases showed high grade dysplasia representing 72%.