الفهرس 
WHO Classification Of Breast Epithelial LesionsOnly 14 pages are availabe for public view
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Abstract
Background: Breast cancer (BC) is the most common type of cancer among
women world-wide and a leading cause of cancer related deaths. Survivin is the
smallest member in the inhibitor of apoptosis (IAP) gene family. It has a potential
dual role in inhibition of apoptosis by inhibiting caspase-9 and cell proliferation
via regulation of mitosis. Survivin overexpression in cancer promotes survival of
aneuploid cells, facilitates bypassing of cell cycle checkpoints and increases
angiogenesis, thereby using its cytoprotective character to ensure tumor
progression.
Objectives: Investigation of immunohistochemical expression of survivin in
breast carcinomas and correlation with the clinico-pathological aspects &
molecular subtypes of the tumors.
Materials and methods: 60 formalin fixed paraffin embedded BC tissue sections
were randomly collected. Both epidemiological data and molecular subtypes were.