الفهرس 
Introduction & Aim of WorkOnly 14 pages are availabe for public view
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Abstract
Introduction: Early diagnosis of varices before the first bleed is essential as studies of primary prophlaxis clearly show that the risk of variceal haemorrhage can be reduced by 50% to about 15% for large oesophageal varices. Aim of the Study: The current work aims to investigate prospectively the available evidence on the usefulness of the combined use of liver stiffness (transient elastography measured by FibroScan) and platelet count as noninvasive means to identify post hepatitis C virus (HCV) - compensated cirrhotic Egyptian patients without oesophageal varices. Main endpoints are the presence of varices. Patients and Methods of Work: This study is performed on 62 post HCV- related compensated cirrhotic patients presented for routine follow up at Internal Medicine Department –Mansoura UNIVERSITY Hospital and The Egyptian Liver Research Institute in Sherbeen. Results: The results revealed that the cutoff value of ≥23.1(KPascal) for LSM, ≥3.71 for FIB4 and ≥130 mm for splenic diameter; have a sensitivity of 94%, 97% and 97% respectively and a specificity of 81%, 81% and 68% to diagnose the presence of varices and that the optimum cutoff value to predict the presence of OV where platelet count of ≥112,500 (X103/dl) and for PSR of ≥771.33 have a sensitivity of 84% and 77% and a specificity of 87% and 90%, respectively to rule out the presence of varices. Recommendation: Our study has limitations, many of which have been discussed. Due to the small numbers of patients included in our study, reassessment of our new variable on a larger number of patients before validation is recommended.This study was a single-center and limited to patients with early liver cirrhosis. In addition, our findings are needed to be confirmed by further multicenter studies and to determine whether these parameters will be of benefit for the more severely affected patients who are unable to do endoscopic screening.