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Abstract Valproate (VPA) which usually prescribed as its sodium salt was approved for treatment of epilepsy either as monotherapy or in combination with other anticonvulsant drugs. It is also used in the treatment of a variety of neuropsychiatric illnesses as mania, bipolar affective disorder, migraine, headache, prophylaxis and several anxiety disorders as It elevates the whole brain gamma amino butyric acid (GABA) a major inhibitory neurotransmitter in the brain, and inhibits GABA degradation (Ibrahim, 2012). It was reported that it has sever toxic effects on liver tissue (Pourahmad et al., 2012).In addition Valproate (VPA) medication is associated with development of polycystic ovaries, menstrual disorders and hormonal changes in women with epilepsy (Røste et al., 2001). It was demonstrated that use of VPA in patients with epilepsy is associated with an increase in body weight by increasing serum insulin and insulin/glucose levels or by stimulating appetite (Kanemura et al., 2012). Metformin is one of the most widely used oral antidiabetic drugs for the treatment of type 2 diabetes (Jiang et al., 2014) as it controls blood glucose levels by increasing insulin sensitivity and improving glucose uptake in the liver(Mori et al., 2017). It additionally finds place in the treatment of many clini |