الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Preeclampsia was defined as the development of hypertension (systolic blood pressure (BP) ≥ 140 mmHg and/or diastolic BP ≥ 90 mmHg on two occasions at least 4 hours apart) and proteinuria (≥0.3 grams in a 24-hour specimen or urine protein/creatinine ratio (uPCR) ≥ 0.3) after the 20th week of gestation in a previously normotensive patient. Severe preeclampsia was defined as preeclampsia complicated by either a systolic BP ≥ 160 mm and/or a diastolic BP ≥ 110 mmHg (on 2 occasions at least 4 hours apart while the patient was on bed rest)
Patient and Method:This study included 90 pregnant women in three groups They were divided into three groups mild preeclampsia (17case), sever preeclampsia (28cases) and normal pregnant women (control group 45cases).TNF- α, lipid profile and β- hCG levels were measured at clinical pathology department. Result: TNF- α, lipid profile and β- hCG levels were significantly elevated in preeclampsia in comparison with control group. Except HDL which was decreased in preeclampsia. TNF- α, lipid Profile and combined markers in differentiating cases with severe PET were excellent ranging from (0.922-1.0) with the highest sensitivity was detected for combined markers (100%) followed by TNF- α, β-hCG , Cholesterol , VLDL (96.3% each) and least was for HDL(70%). Specificity was highest among combined markers, TNF- α, BHCG (98.4% each) with the least specificity was detected for TG & LDL (87.3% each).The best detected cut off points from the curves for TNF- α, and BHCG were (263.62& 93.12, respectively). Conclusion: Based on our study, altered levels of TNF-α , lipid profile (particularly triglyceride) as well as β- hCG seem to be associated with preeclampsia and moderately to strongly correlated with the severity of disease .In addition, combined biomarkers have 100% and 98.4% sensitivity and specificity in prediction sever preeclampsia.