الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Mitral valve prolapse (MVP) is one of the most common mitral valve abnormalities affecting about 2-3% of the general population. Although it is generally considered a benign condition, it can lead to serious complications including significant MR, heart failure, infective endocarditis, stroke, cardiac arrhythmias and even SCD.
As the risk of MVP-related SCD appears to be higher than initially reported, it is important to identify higher risk patients with MVP who are prone to this fatal complication. Till now, there are no definite criteria that can predict the incidence of life threatening ventricular arrhythmias in patients with MVP.
Our study was designed to identify if there are specific clinical, electrocardiographic and echocardiographic criteria that can predict the occurrence of ventricular arrhythmias in patients with mitral valve prolapse.
In our study, we prospectively enrolled 50 consecutive patients with MVP. All patients were subjected to history taking, clinical examination, resting electrocardiography (ECG), echocardiography (standard and speckle tracking) and 24 hours Holter monitoring. The majority of cases were females (n=41, 82%) with a mean age of 32.40 ± 12.62 years. The patients were further divided into two groups: arrhythmic MVP (12 patients) and non- arrhythmic MVP (38 patients) based on the presence of complex ventricular arrhythmias in Holter monitoring.
We demonstrated several differences between arrhythmic and non- arrhythmic MVP, including demographic, echocardiographic and electrocardiographic characteristics. Patients in the arrhythmia group were significantly older and experienced dyspnea and syncope more frequently than the NA-MVP group. They also had slower resting HR and greater utilization of beta- blockers (BB) and antiarrhythmic drugs.
On echocardiography, the A-MVP cases had larger indexed LV end systolic and end diastolic volumes compared to the NA-MVP group despite similar LVEF and GLS and similar grades of MR. They also had wider mitral annular disjunction and more commonly had posterior leaflet thickness ≥ 5 mm.