الفهرس 
ChemotherapyOnly 14 pages are availabe for public view
 |  | from | 123 |  |  |
| | | from | 123 | | |
Abstract
Vepesid is chemotherapeutic drugs that inhibit topoisomerase II activity and long been used for treatment of human malignancies, where it is a semi-synthetic compound derived from the plant Podophyllum peltatum. The current study was designed to investigate the possible protective effect of rosemary extract against Vepesid -induced changes in liver and kidney functions, and DNA damage in rats. A total of 50 male Wistar albino rats were divided randomly into four groups (1st group was control; 2nd group was treated with rosemary, 3rd group was received Vepesid, and 4th & 5th groups was co- and post treated groups respectively). The administration of Vepesid revealed a significant increase in serum ALT, AST, ALP, creatinine, urea, potassium ions, chloride ions, and DNA damage. In contrast; a significant decrease in albumen, total proteins, sodium ions, and calcium ions were when compared with control group. This increased in ALT, AST, ALP, creatinine, urea, potassium ions, chloride ions,and DNA damage was reduced after administration of rosemary when co-treated with Vepesid (G4), or post-treated after Vepesid (G5) for six weeks with lowest damage in G4. Also, this declined in albumen, total proteins, sodium ions, and calcium ions was elevator after administration of rosemary when co-treated with Vepesid (G4), or post-treated after Vepesid (G5) for six weeks with lowest damage in G4. It could be concluded that rosemary has a promising role and it worth to be considered as a natural substance for protective the liver and kidney toxicity induced by Vepesid chemotherapy.