الفهرس 
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Abstract
In the present study, the aim was to study of hepatitis C virus as a possible risk factor for Parkinson’s disease.
The study was conducted on 20 patients diagnosed as Parkinson’s disease according to (UPDRS), recruited from the outpatient clinics of Al Hadara University hospital. The Ten consecutive Parkinson’s patients were proved as HCV infected using PCR test and MRI brain done at the main Alexandria university hospital.
Patients with the following criteria were excluded: those having PD caused by other reasons, such as secondary Parkinson caused by vascular disease, drug-induced parkinsonism, and Parkinson plus syndrome such as multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, and dementia with Lewy body, patients with severe hepatic impairment, patients having other chronic viral infection, alcoholic liver cirrhosis, hepatocellular carcinoma, patients having other chronic diseases such as diabetes, hypertension, ischemic heart disease, and ischemic stroke, brain tumour, hepatic encephalopathy.
group 1 include 6 males (60%) and 4 females (40%). their ages ranged from 52.0 75.0 years with a mean age of 63.50 ± 8.77 years, while group 2 include 8 males (80%) and 2 females (20%). their ages ranged from 52.0 77.0 years with a mean age of 65.10 ± 8.67 years.
Ethical approval and written informed consent were taken from all patients. Complete history taking including: age, sex, age of onset of PD, previous medical and surgical history, family history and thorough clinical, neurological and abdominal examination were done for all studied patients.
• Scaling of PD disability, using movement disorder society- Unified Parkinson Disease Rating Scale.
• Conventional magnetic resonance imaging brain study including:
a. T1 weighted axial and sagittal sequences
b. T2 weighted axial and coronal sequences
c. Axial Fluid –attenuated inversion recovery (FLAIR)
d. Diffusion weighted image and ADC map.
e. Magnetic resonance spectroscopy.
All MRI sequences were performed using a standard head coil on a 1.5 tesla MR system Ingenia (Philips Medical systems Nederland B.V. Veenpluis 4-6, 5684 PC Best, The Netherlands).All patients were asked to get rid of any metallic subjects as well as they were asked about any contraindication to MRI examination (artificial heart valve, cardiac pacemaker, metallic stents or joint prosthesis except that made of titanium). The patients were informed about the duration of the examination, the position of the patient and the importance of being motionless.