الفهرس 
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Abstract
Asthma is a chronic inflammatory disorder of the airways in which many inflammatory cells and proinflammatory cytokines play a role. Asthma is epidemiologically linked with type 2 diabetes mellitus. Several mechanisms have been suggested to explain the association between asthma and T2DM including genetic pleiotropy, epigenetic factors, mitochondrial dysfunction, direct effects of hypoxia on glucose metabolism, common inflammatory cytokines such as interleukin 6 and interleukin 17 , inflammatory effect and hormonal effect of GLP1.
GLP1 is considered as an incretin hormone that has anti-inflammatory actions and GLP1 receptor agonists are widely used in treatment of T2DM. GLP1 receptor is a G protein coupled receptor that is distributed widely in beta cells of pancreas, heart, kidney, intestine, liver, nervous system and lung. Yet, its function in the lung is poorly understood.
The aim of our work was to investigate the potential involvement of GLP1R in the pathophysiology of concomitant type 2 diabetes mellitus and asthma. The present study was conducted on 40 participants; grouped into10 non asthmatic non diabetic subjects, 10 asthmatic patients (as defined by GINAguidelines), 10 diabetic patients (as defined by ADA) and 10 patients with diabetes and asthma.
The following investigations were carried out on all participants:
1) Anthropometric measurements including weight, height, waist circumference and BMI.
2) Pulmonary function testing including FEV1, FVC, FEV1/FVC% and MMEF using a dry spirometer.
3) Methacholineinhalation challenge (MIC) using automated dosimeter.
4) Assessment of fasting blood glucose, fasting insulin and calculation of insulin resistance.
5) Measurement of glucagon like peptide-1 receptor (GLP1 R) level in serum and sputum by ELISA.
6) Data was calculated and analyzed using the statistical package of social science (SPSS version 20 Armonk, NY: IBM Corp).
Our results revealed that:
• GLP1 receptor exists in both serum and sputum of all participants.
• Diabetes- associated asthma group exhibited lower level of MMEF than diabetic and control groups.
• There is a significant reduction in GLP1R level in the serum and sputum of patients with diabetes and asthma than control subjects indicating the possible involvement of GLP1R disturbance in the pathophysiology of concomitant type 2 diabetes mellitus and asthma
• A positive significant correlation between MMEF and GLP1R concentration in patients with diabetes and asthma suggests that the reduction in GLP1R may be a drive tosmall airway inflammation in this group.