الفهرس 
Title pageOnly 14 pages are availabe for public view
 |  | from | 84 |  |  |
| | | from | 84 | | |
Abstract
Breast cancer is a heterogenous diseaseand has been classified into different histologic types. In addition, breast cancer is classified in to intrinsic molecular subtypes by gene expression profiling namely Luminal-A, Luminal-B, HER-2 enriched, and triple negative breast cancers. Each of these has a variable incidence, risk factors, prognosis and sensitivity to treatment.
Cyclin D1 overexpression has been reported in up to 50% of human breast cancers.cyclin D1 has a pivotal role in promoting cell cycle progression.Studies on cyclin D1 in invasive breast carcinoma have shown both positive and negative prognostic impacts. Thus, Studies on Cyclin D1 have shown inconsistent and conflicting results with regard to its role in pathogenesis and also prognosis.
Aim: The present work aims at the study of cyclin D1 expression in invasive carcinoma of the breast, and to analyze its relationship with other prognostic factors of breast cancer which are tumor size, histological grades, axillary lymph node metastasis, vascular invasion and histological subtype as well as estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER-2).
Materials and methods: The present work studied the immunohistochemical expression of cyclin D1 in 60 cases of invasive breast carcinoma with different hormone receptor/ Her 2 status and histologic subtypes.
Results: 30 cases showed strong immunohistochemical expression of cyclin D1, 18 cases showed weak immunohitochemical expression of cyclin D1, 12 cases showed negative expression of cyclin D1.
There was a statistically significant correlation between cyclin D1 expression and tumor size, histologic subtype, histologic grade,ER status, PR status, Her 2 status and subtypes according to hormone receptors / Her 2 status.
There was no statistically significant correlation between cyclin D1 expression and axillary lymph node metatstasis, vascular invasion, and age.