الفهرس 
Physiologic Changes with AgingOnly 14 pages are availabe for public view
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Abstract
Summary and Conclusion The risk of cancer increases exponentially with age. About 60% of cancers occur in people 65 years of age or older and about 70% of the deaths caused by cancers occur in this stage. Therefore, cancer is a disease of old age. Chemotherapy remains a standard component of cancer treatment. However, older patients are also at increased risk for chemotherapy toxicity. Actually the elderly form a very heterogeneous group in relation to their general health state, degree of dependence, comorbidities, performance status, physical reserve and geriatric situation, for which therapeutic decisions must be made in an individualized manner. In addition, changes in pharmacokinetics and pharmacodynamics of the drugs occur with age, as well as the tolerance of the tissues, leading to a narrowing of the therapeutic margin and an increase in toxicity. The CARG score was developed in a prospective multicenter cohort study of 500 patients age 65 or older with cancer who were receiving chemotherapy. All patients underwent a GA that included measures of functional status, comorbidity, psychological state, social activity, social support, and nutrition. A predictive model was developed and validated. This study was designed to identify fit older patients who can receive standard cancer treatments by prediction