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Abstract This study shows that deficiency of vitamin D in chronic renal failure patients is associated with high level of intact parathyroid hormone (hyperparathyroidism), also vitamin D receptor gene FOKI polymorphism had effect on the levels of iPTH. F allele in VDR FOKI polymorphism was shown to have a higher incidence in the development of sHPT in CRF patients. Deficiency of vitamin D, high level of iPTH and its association with VDR gene polymorphism may be used as morbidity indicator and risk factors for identification the high risk group in chronic renal failure patients. Further, this study recommends more genetic studies about the role of vitamin D and parathyroid hormone in chronic renal failure patients on a large scale of patients. |