الفهرس 
ZincOnly 14 pages are availabe for public view
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Abstract
Background: Zinc is an essential micronutrient for human beings and its deficiency affects their normal growth and development. Although the prevalence of zinc deficiency is still unclear in patients with maintenance hemodialysis (MHD), some data show adverse outcomes that may attribute to zinc deficiency. Aim of the Work: to assess if zinc supplementation has a role in decreasing the inflammatory markers levels in hemodialysis patients with zinc deficiency; 60 patients (20 healthy people as control – 40 patients ESRD on regular hemodialysis). Patients and Methods: A cohort prospective interventional study was conducted on 60 patients (20 healthy people as control – 40 patients ESRD on regular hemodialysis) at Dialysis unit of Ain Shams University during a period of 6 months. Results that zinc level was significantly lower in ESRD ( 8.33 ) umol/l compared to the healthy control group (13.33 )umol/l ( normal level of zinc 12.5-18.5 umol/l the inflammatory markers were significantly higher in ESRD who had zinc deficiency HSCRP (9565.7)mg/l , IL6 ( 57.8 ) pg/ml compared to the ESRD patients who had normal zinc After zinc supplementations to ESRD patients who had zinc deficiency we found that The zinc level increased significantly from ( 7. 1± 1.1 )umol/l to ( 14.3± 1.8 )umol/ l . inflammatory markers level was significantly decreased, HS CRP Level from ( 9565.7 ± 259307 )mg/l to (4708 ± 2235.4) mg/l , IL6 level from (57.8 ± 16.5 )pg/ml to (28.0 ± 9.1 )pg/ml Conclusion: Zinc deficiency in ESRD on regular hemodialysis is more than in normal population which increase the inflammation response and, high HSCRP and IL6 as a inflammatory markers, after correction of zinc deficiency in ESRD, the inflammatory markers is decreased and the inflammations is improved , and has a positive effect to Hb and Ca.