الفهرس 
Part I: General introduction
IntroductionOnly 14 pages are availabe for public view
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Abstract
Part I: General introduction: This part provides an over view about pharmaceutical importance and chemical structure of the studied drugs. The analytical review for the analytical techniques used for determination of the studied drugs in. At the end of this part the objective of the suggested work was discussed.
Part II: Utility of π-acceptor reagents for spectrophotometric determination of atomoxetine drug via charge-transfer complex formation.
This part describes two simple and selective methods proposed for the spectrophotometric determination of atomoxetine hydrochloride in bulk form and in pharmaceutical capsule. The two methods are based on the formation of charge-transfer complexes between the drug base as a n-donor and p-chloranil and 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) as π-acceptors. Under the optimum reaction condition, Beer’s law was obeyed over the concentration range of 30-320 and 10-80 µg ml-1 for p-chloranil and DDQ respectively.
Part III: Studying the association complex formation of atomoxetine and fluvoxamine with Eosin Y and its application in their fluorimetric determination.
In this part a simple, sensitive and non-extractive spectrofluorimetric method has been developed and validated for the determination of atomoxetine and fluvoxamine in pure forms and pharmaceutical dosage forms. The proposed method is based on the formation of binary complexes between eosin Y and the studied drugs in the presence of Teorell-Stenhagen buffer. The quenching of the native fluorescence of eosin Y due to complex formation with the studied drugs was measured spectrofluorimetrically at 545 nm after excitation at 302 nm.
Part IV: Utility of Hantzsch reaction for sensitive spectrofluorimetric determination of fluvoxamine in pure form and pharmaceutical formulation.
This part is devoted to the development of a sensitive, economic, and accurate spectrofluorimetric for the determination of fluvoxamine in pure form and pharmaceutical formulation. The method is based on the condensation of the primary amine group of fluvoxamine with acetylacetone and formaldehyde in the presence of acetate buffer pH 4.2. The formed yellow fluorescent products can be measured spectrofluorimetrically at 479 nm after excitation at 419 nm.. The proposed method was applied successfully for determination of this drug in its pharmaceutical dosage form.
Part V: Stress degradation study and selective spectrofluorimetric determination of fluvoxamine in pharmaceutical formulation.
This part describes the development and validation of a simple and sensitive spectrofluorimetric for determination of fluvoxamine maleate (FXM). The proposed method is based on condensation reaction of the primary amino group of FXM with ninhydrin and phenylacetaldehyde in buffered medium (pH 6.6) to form a highly fluorescent product measured at 482 nm after excitation at 386 nm. Reaction condition were carefully studied and optimized and the calibration curve was linear over the concentration range of 0.8–14 µg mL-1 with a limit of detection (LOD) of 0.25 µg mL-1.
This thesis includes a list of 129 References. In addition, it comprises 28 tables, 27 figures and 4 schemes, as well as a summary in English and in Arabic.