الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 159 |  |  |
| | | from | 159 | | |
Abstract
Sirtuins (SIRTs) are members of the silent information regulator 2 family. SIRT1 exerts anti-apoptotic, anti-oxidative, and anti-inflammatory effects against cellular injury, and protects the cells through the regulation of mitochondrial biogenesis, autophagy, and metabolism.SIRT1 also promotes vasodilation and protects vascular tissues. In humans with diabetic kidney disease (DKD), its expression tends to be decreased in renal cells. SIRT1 gene polymorphism was detected using real -timePCR in a total number of 50 subjects, 40 type 2 diabetic patients with diabetic kidney disease (DKD) and 10 diabetics without DKD as a control subjects. The subjects were divided in to 3 groups; (group I), included (20) type 2 diabetic patients with DKD, with albuminuria [A/C ratio > 30 mg/g], (group II), included (20) type 2 diabetic patients with DKD, without albuminuria [A/C ratio < 30 mg/g], and (group III), (10) type 2 diabetic patients as a controls without DKD. The following investigations were done: fasting blood glucose (mg/dl), total cholesterol (mg/dl), triglycerides (mg/dl), HDL-c (mg/dl), LDL-c (mg/dl), serum creatinine (mg/dl), HbA1c (%), ACR (mg/g), eGFR (ml/min/1.73m²). As regards age, sex, BMI and blood pressure there were no significant difference between the three studied groups, while there was significant increase in duration of DM, HbA1c, 2hr PPG, TC, TG, LDC,Urea,Creatinine and ACR and significant decrease in HDL-C and eGFR in diabetics with DKD when compared to those without DKD.