الفهرس 
Gross anatomy and MR anatomy of the bonesOnly 14 pages are availabe for public view
 |  | from | 141 |  |  |
| | | from | 141 | | |
Abstract
Background: Osteosarcoma (OS) is the most common malignant bone tumor in children and adolescents. Currently, 10-year overall survival rates are 60% to 70% for all patients and only approximately 20% for patients with metastatic disease.
Aim of the Work: To investigate whether diffusion-weighted imaging (DWI) is useful for monitoring the therapeutic response after chemotherapy in osteosarcoma by comparing the ADC values pre and post chemotherapeutic treatment. To determine if osteosarcomas change their water diffusion during preoperative chemotherapy in relation to the amount of tumour necrosis.
Patients and Methods: This is a retrospective study included 30 patients (18 females & 12 males), their ages range from 7 to 36 years. Mean age 14.8 years. The study was performed Radiology Department at Ain-Shams University Hospitals between September 2018 & Dec 2019.
Results: Most of cases about 50 % show partial response according to RECIST criteria.
Conclusion: Chemotheraphy is effective in reducing size, increase tissue breakdown and improvement of cases of osteosarcomas according to results of this study.