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العنوان
The Reactivity of Some π-Deficient Compounds Towards Nitrogen and Sulfur Containing Nucleophilies /
المؤلف
Mohamed, Hendawy Nagaty Tawfeek.
هيئة الاعداد
باحث / هنداوي نجاتي توفيق محمد
مشرف / علاءالدين عبدالحفيظ حسن
مشرف / نصر كامل محمد
مشرف / أشرف عبدالمنعم علي
الموضوع
Chemistry.
تاريخ النشر
2020.
عدد الصفحات
300 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
Organic Chemistry
تاريخ الإجازة
1/1/2020
مكان الإجازة
جامعة المنيا - كلية العلوم - كيمياء عضوية
الفهرس
Only 14 pages are availabe for public view

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Abstract

Aim of the work:
The main goals of our studies are:
 Construction of a novel heterocyclic compounds containing nitrogen and sulfur.
 Elucidate the structure of the synthesized compounds using spectroscopic tools such as IR, 1H NMR, 13C NMR spectroscopy, mass spectrometry and elemental analyses.
 Confirmation of the structures using X-ray crystallography analyses.
 Detection of the reactive sites in donor compounds, the mode of cyclization, and rationale for the formation of the products.
 Overviewing the general applications of the synthesized heterocyclic nucleus.
Introduction:- Discuss the structure features of thiazine derivatives, their biological activity, methods of preparation as well as the chemical reactions.
In The results and discussion: Thiosemicarbazide derivatives have been used as nitrogen and sulfur containing compounds (electron-donors) to react with –deficient compounds (electron acceptors).
Part 1: The reaction between thiosemicarbazides with 2,3-diphenylcyclopropenone furnished the thiazinane derivatives as well as the acrylohydrazide.
Part 2: While, the reaction between thiosemi-carbazides with 2,3,5,6-tetrachlorobenzoquinone using Eshenmoser-contracting to give the diazinyltriazole derivatives.
Part 3: On the other hand, thiosemiicarbazides have been reacted with phenacylbromide derivatives and thiazole derivatives have been obtained.
Part 4: On reacting, thiosemicarbazides with indandionemethylene dicarbonitrile (CNIND), fused heterocyclic [3.3.3.]propellane s have been obtained.
Part 5: Lastly, the reaction between thiosemi-carbazides with dialkyl acetylenedicarboxylate gave the thiazolidinone derivaties.
The chemical structures of the obtained compounds have been determined using spectroscopic analyses (IR, HNMR, and CNMR) and mass sspectometry. The X-ray crystallography have been used to confirm the structures.