الفهرس 
Induction of abortionOnly 14 pages are availabe for public view
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Abstract
Background: Medical abortion, the termination of pregnancy through the use of a drug or a combination of drugs, has the potential to reduce complications and to expand access to abortion provided not only by specially trained clinicians but also by other health care providers who may or may not have training in surgical methods of abortion Aim of the study: to determine the effect of intravenous dexamethasone on preparing the cervix and induction of abortion in second trimester in pregnant women at gestational age 16-24 weeks. Patients and Methods: This study was carried out between July 2018 and December 2019, at the labor ward of Ain Shams university maternity hospital, a randomized controlled trial of 140 pregnant women undergoing induction of abortion after obtaining the approval of the local ethical committee and a fully-informed written consent. They were randomized into two groups: group I (dexamethasone group n=70) and group II (control(Misoprostol) group n=40). Results: Of 140 pregnant women undergoing induction of abortion there were no statistically significant differences between the two groups as regard their age, body mass index, gestational age , parity and number of previous abortions at time of intervention. There was significant statistical difference between the two groups as regard induction-expulsion interval (P = 0.001) and length of hospital stay (P = 0.001), mean induction-expulsion interval in group I was (10.5 hours) while in group II was (17.5 hours) , the mean length hospital stay was 16 hours in the dexamethasone group while was 23 hours in the control group.There was no significant statistical difference between the two groups as regard timing of abortion. There was significant statistical difference between the two groups as regard dose of misoprostol used (P=0.001),mean dose of misoprostol in the dexamethasone group was 800 mcg while was 1600 mcg in the control group .There were no statistically significant differences between the two groups as regard need for second cycle , blood transfusion and hysterotomy .There was no significant statistical difference between both groups as regard fever and need for surgical evacuation . None of our patient needed hysterectomy . Fever (P=0.149), Surgical evacuation (P=0.439). Conclusion: the administration of dexamethasone intra- venously 8 mg 8 and 4 hours before the medical induction of abortion by misoprostol (400 mcg intra vaginally every 3hr) appears to be effective as regard shortening the induction-abortion interval, the length of hospital stay and decreasing the total dose of misoprostol.