الفهرس 
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Abstract
Nephrotic syndrome is a well-recognised chronic illness in childhood.
There is marked urinary loss of proteins such as albumin, hormones
and hormones binding proteins leading to reduce the binding capacity for
thyroid hormones, resulting in a decrease in total tri-iodothyronine (T3)
and thyroxin (T4) concentrations.
The present study had been performed at Pediatric Nephrology clinic
and Pediatric Inpatient department at Sohag University Hospital from
January to December ,2017.
It included 51 patients with nephrotic syndrome . we found that during
nephrotic attack serum albumin and serum total proteins were low while
serum cholesterol and triglycerides were high .
We found that the studied patients have high serum TSH level while
serum TT3 and TT4 were reduced during nephrotic attack.
Our study showed that during nephrotic attack about 47% of study
group had subclinical hypothyroidism , while overt hypothyroidismwas
found in 23% of studied patients.
We found that only one case of nephrotic patients has overt
hypothyroidism and about 27% of them have subclinical
hypothyroidism after remission.
We concluded from this study that nephrotic syndrome patients have a
state of hypothyroidism so, we recommended routine thyroid screening in
patients with nephrotic syndrome.